Brenner_Photo Stacey Brenner-Moyer
office: Life Science Center 201E

Research Interests

We are a synthetic organic chemistry group whose research is at the frontier of organic synthesis, catalysis and medicinal chemistry. We develop new catalytic asymmetric reactions that we, and others, can use in the synthesis of natural products and drugs. Specifically, we have developed a number of cascade reactions, in which multiple synthetic steps are carried out in a single reaction flask, and that are catalyzed by organic molecules, which are known as organocatalysts. The methods we develop can thus reduce the time, waste, and cost associated with the conventional organic synthesis of valuable synthons. In addition, we are interested in developing fluorinated analogues of select small bioactive molecules using the cascade reactions involving fluorination that we have developed.

Selected Publications

  1. Jones, J.H.; Appayee, C.; Brenner-Moyer, S.E. "One-pot preparation of enantiopure fluorinated beta-amino acid precursors." Eur. J. Org. Chem. 2014, in press. [doi]
  2. Appayee, C.; Fraboni, A.J.; Brenner-Moyer, S.E. "γ-Amino alcohols via organocascade reactions involving dienamine catalysis." J. Org. Chem. 2012, 77, 8828-8834. [doi]
  3. McGarraugh, P.G.; Brenner-Moyer, S.E. "An organocascade kinetic resolution." Org. Lett. 2011, 13, 6460-6463. [doi]
  4. Appayee, C.; Brenner-Moyer, S.E. "Organocatalytic enantioselective olefin aminofluorination." Org. Lett. 2010, 72, 3356-3359. [doi] (Highlighted in Synfacts)
  5. McGarraugh, P.G.; Brenner, S.E. "A new organocatalyzed Michael-Michael cascade reaction generates highly substituted fused carbocycles." Org. Lett. 2009, 11, 5654-5657. [doi] (Highlighted in Synfacts)

    For more detail, please see the Brenner-Moyer Group Web Page